Palladium catalyzed oxidative aminations and oxylations: where are we?

Mélanie M. Lorion (1) , Julie Oble (1) , Giovanni Poli (1)

1 IPCM - Institut Parisien de Chimie Moléculaire

Selective product formation in the Pd-catalyzed cyclization of unsaturated amide and carboxylic acid derivatives is an intriguing and challenging task. We recently discovered that the oxidative intramo-lecular Pd(II)-catalyzed amination or oxylation of unsaturated N-sulfonyl carbamates, N-sulfonyl carbox-amides and carboxylic acids takes place through the involvement of cyclic (usually, 5-or 6-membered) aminopalladated (AmPIs) or oxypalladated (OxPI) intermediates. Such cyclic intermediates can undergo a variety of transformations such as distocyclic β-H elimination, oxidative acetoxylation or intramolecular car-bopalladation, depending upon the substrate and/or the reaction conditions. In the absence of appropriate reaction pathways, the cyclic nucleopalladated intermediates (NuPIs) simply engage in an inconsequential equilibrium with the initial substrate and other transformations occur such as allylic C–H activation or, in the particular case of allyl carbamates, [3,3]-sigmatropic rearrangement.

Mots clés: aminopalladation; C–H activation; C–H bond reactivity; ESOC-19; β-hydride elimination; nucleo-palladation; oxypalladation; palladium (II); palladium catalysis; [3.3]-sigmatropic rearrangement

Domaines: Catalyse; Chimie organique

Mélanie M. Lorion, Julie Oble, Giovanni Poli. Palladium catalyzed oxidative aminations and oxylations: where are we?. Pure and Applied Chemistry, 2016, 88 (4), pp.381-389. ⟨10.1515/pac-2015-1102⟩. ⟨hal-01339402⟩